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at the proximal interphalangeal joint, hyperflexion at the distal interphalangeal joint). The thumb may 400mg celebrex information patient vioxx a Z-Thumb deformity with fixed flexion and subluxation at the metacarpophalangeal joint, leading to a squared appearance in the hand.Extra-articular manifestations also distinguish this disease from osteoarthritis (hence it is a multisystemic disease). For example, most patients also suffer of 400mg celebrex information patient vioxx either as a consequence of the disease itself (anaemia of chronic disease) or as a consequence of gastrointestinal bleeding 400mg celebrex information patient vioxx a side effect of drugs used in treatment, especially NSAIDs (non-steroidal anti-inflammatory drugs) used for analgesia. Splenomegaly may occur with concurrent leukopaenia (Feltys syndrome), 400mg celebrex information patient vioxx lymphocytic infiltration 400mg celebrex information patient vioxx affect the salivary and lacrimal glands (Sjogrens syndrome).Dermatological: Subcutaneous nodules on extensor 400mg celebrex information patient vioxx such as the elbows, are often present.Pulmonary: The lungs may become involved as a part of the primary disease process or disease.
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